Neurodegenerative Diseases: Translational Models, Mechanisms, and Therapeutics

This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches.Key Features: Provides a comprehensive overview of neurodegenerative diseases and their models Examines the limitations associated with modeling neurodegenerative diseases Presents novel treatment strategies for Alzheimer's disease using cellular models Reviews importance of 3D organoid models for therapeutic approaches in Parkinson's disease Covers modeling techniques in understanding prion diseases Explores the role of genetic models in understanding Huntington's disease

About the Author

Dr. Sachchida Nand Rai is a Research Associate (ICMR-RA) at Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University (BHU), Varanasi since 27th Jan 2023. Dr. Rai also completed his Ph.D from the Biochemistry Department (Institute of Science) from BHU. Before joining the BHU as Research Associate, he was post-Doctoral fellow at Centre of Biotechnology, University of Allahabad, Prayagraj, India. He has published several research articles in high impact journals and has published 3 books. Dr. Rai serves as editorial board member in many reputed journals. He is investigating the neuroprotective activity of common Indian medicinal plants in toxin induced Parkinsonian mouse model. He is also member of the Indian Academy of Neurosciences, (India).

Dr. Sandeep Singh is a Post-Doctoral Fellow at Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, California, USA. Before joining the Salk Institute, he was post-Doctoral fellow at Hadassah Biological Psychiatry Laboratory, Hadassah - Hebrew University Medical Center, Jerusalem, Israel. During PhD, he has presented his work in many world-renowned international neuroscience conferences such as Society for Neuroscience (USA), International Society for Neurochemistry (Paris), Japan Neuroscience Society (Japan). He was a recipient of IBRO-APRC Exchange Fellowship (2019) to work at National Institute of Advanced Industrial Science & Technology (AIST), Japan and Senior Research fellowship (2018) from Indian Council of Medical Research, India. He has published several research articles in journals of high repute. He is investigating the potential role of natural compounds and how they modulate the different molecular pathways during aging and age associated diseases. He is also member of the Indian Science Congress Association (India), Indian Academy of Neurosciences, (India).

Dr. Santosh Kumar Singh is a Senior Scientist at Centre of Experimental Medicine and Surgery (CEMS), Faculty of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India. He has completed his Ph.D. from the Botany Department (Institute of Science), BHU in 1998. He was a Visiting Scientist at Department of Photosynthesis, Institute of Physical Biology, University of South Bohemia, Czech Republic, in 2003. He has published more than 75 research articles in high impact factor journal and has published several books. Drug Discovery & Development, Microbial Biotechnology and Nanobiotechnology are some of his major areas of research. He is also Life time member of Mycological society of India, Life time member of Society of Biological Chemists, India, Member of the Society for Ethnopharmacology, Kolkata, India (SFE-INDIA). He was also participated as resource person in Karyashala Training Course Under Accelerate Vigyan Scheme, SERB, DST. He was awarded with “National Award for “Outstanding Efforts in Science and Technology Communication through Innovative and Traditional methods (2021)” conferred by Department of Science and Technology, Ministry of Science and Technology, Government of India. He was also received the order of academic excellence in publication (2020-2021), Institute of Medical Sciences, Banaras Hindu University, Varanasi.