Multicomponent Reactions: Applications in Organic Synthesis and Drug Discovery

Comprehensive coverage of sustainable multicomponent reactions across multiple disciplines Multicomponent reactions (MCRs) enable the combination of three or more starting materials in a single vessel to afford diverse and complex products while aligning with green chemistry principles. Multicomponent Reactions: Applications in Organic Synthesis and Drug Discovery summarizes the most recent MCR applications and emerging trends, providing expert knowledge on current advancements across organic chemistry, medicinal chemistry, polymer and analytical chemistry. The book explores sustainable chemical approaches, such as electrochemistry, photochemistry, mechanochemistry, and flow chemistry. It also covers biocatalytic MCRs, reactions in non-conventional solvents, isotope labeling, and late-stage functionalization. Additional topics include: Artificial intelligence and automated synthesis (HTS) enhancing MCRs workflows in research laboratories Drug discovery applications demonstrating how MCRs rapidly generate diverse chemical libraries of heterocycles and bioactive compounds, including protein degraders Reactive intermediates and reaction mechanisms in multicomponent processes Innovative approaches for designing advanced materials with specific functional properties MCRs in chemical education Multicomponent Reactions: Applications in Organic Synthesis and Drug Discovery will benefit organic chemists, medicinal chemists, materials scientists, and chemical engineers, providing them with practical knowledge of sustainable synthetic methods from expert contributors across various research fields.

About the Author

Mariateresa Giustiniano is an associate professor at the University of Naples Federico II in Italy. She has co-authored over 60 peer-reviewed publications and four book chapters, with research interests spanning multicomponent reactions, visible-light photocatalysis, and their application in medicinal chemistry for discovering new anticancer agents.