Mesenchymal Stromal Cells: Biology and Clinical Applications

Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs. This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs.Features include: Coverage of the biology of MSCs, latest understanding of mechanisms of action, and role in tissue homeostasis and regeneration Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues.

About the Author

Peiman Hematti, MD is Associate Professor of Medicine, Pediatrics, Surgery and Biomedical Engineering at the University of Wisconsin-Madison, School of Medicine and Public Health.  He obtained his MD degree from Tehran University, School of Medicine, completed residencies in internal medicine and pediatrics at the Cleveland Clinic Foundation, and a clinical and research fellowship in hematology at National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, Maryland. He joined UW-Madison in 2004 as a bone marrow transplant physician and soon became the director of Clinical Hematopoietic Cell Processing Laboratory, and Director of Bone Marrow Collection, Apheresis and Processing Center, at University of Wisconsin-Hospital and Clinics. His clinical research interests are in the use of mesenchymal stromal cells for treatment of graft versus host disease and other immune dysregulation disorders, novel cellular therapies for hematological malignancies, and use of bone marrow stem cells in regenerative medicine. His laboratory research focuses on investigating the immune modulatory properties of mesenchymal stromal cells with a focus on their interactions with macrophages. He is collaborating with many investigators from a wide range of disciplines at the local, national, and international levels studying the potential of mesenchymal stromal cells in many different in vitro and in vivo pre-clinical models with the ultimate goal of using these cells in clinical trials. He is co-principal investigator of UW-Madison “Production Assistance for Cellular Therapies” (PACT) award from NHLBI-NIH, and 2012-chair of PACT Education Steering Committee. He has been recently selected to serve as the American Society of Hematology representative to the AABB Cellular Therapies Standards Program Unit. Dr. Hematti is on editorial board of several journals including Experimental Hematology and Cytotherapy. He has numerous manuscripts and bookchapters published in the field of mesenchymal stromal cells.