Medical Biostatistics, Fifth Edition

This book presents statistical methods from a medical perspective, emphasising their application in clinical research and healthcare decision-making. It prioritises the medical and bio components over the statistical, ensuring accessibility for medical professionals. The fifth edition streamlines content while maintaining comprehensive coverage of essential biostatistical concepts. Further details of intricate methods are available online for those interested. Includes newer methods regarding agreement assessment, assessment of predictivity of models, SAMPL guidelines for reporting, lower P-values, sample size, machine learning models, personalised statistical medicine, etc. Offers new insights on the need for medical significance, studies on small samples, assessment of clinical agreement, correct assessment of prediction models, AI in research methods, and measurement of positive health. Covers research methodology, clinimetrics, quality of research, and statistical fallacies, with focus on medical applications rather than statistical theory. Presents probability, odds ratios, ordinary and logistic multivariable regressions, ROC curves, predictivities, confidence intervals, parametric and nonparametric tests, survival analysis, sample sizes for different setups, introduction to multivariate methods such as discriminant functions, cluster analysis, and factor analysis, and more. Provides summary tables guiding readers on method selection - an extremely user-friendly feature. Every chapter includes medical case studies and exercises. Solutions to selected exercises are provided. In addition, solution of intricate problems using R-software, and other additional material is available online. This book is for students, professionals, and practitioners in statistics, medicine, pharmacy, and nursing. This book is a comprehensive resource for medical researchers seeking statistical guidance for their studies.

About the Author

Abhaya Indrayan , MSc, MS, PhD, FAMS, FRSS, FASc, is currently President of the Biostatistics Consortium and Biostatistics Consultant at Max Healthcare, New Delhi. He is also a Former Professor of Biostatistics at Delhi University College of Medical Sciences.

He holds a PhD in Biostatistics from The Ohio State University. He has served as Founder Professor and Head of the Department of Biostatistics and Medical Informatics at Delhi University College of Medical Sciences, Delhi. He has contributed more than 330 publications to reputed journals and presented papers at 17 international conferences. In the past, he has been affiliated with The Ohio State University as Visiting Faculty and with the University of Massachusetts as Visiting Research Scientist. He has also acted as Adviser to the World Health Organization, The World Bank, and UNAIDS for more than 30 projects.

He has authored several books including Concise Encyclopedia of Biostatistics for Medical Professionals ; Medical Biostatistics, Fifth Edition ; and Research Methods for Medical Graduates , all published by CRC Press.

Rajeev Kumar Malhotra is a former Senior Scientist (Statistics) at All Indian institute of Medical Sciences (AIIMS) New Delhi. He received his PhD in Biostatistics from the University of Delhi and has more than 33 years of experience in the design, conduct and statistical analysis of Clinical trials, observational studies, and survival analysis.

He contributed as co-supervisor for more than 25 MD/DM students. His areas of expertise include time-to-event analysis, sample size determination, longitudinal data analysis, GEE, and advance statistical methods for oncology research.

He has authored over 130 peer-reviewed publications in peer-reviewed National and International medical journals and contributed chapters in several books. He has been awarded as a Member of National Academic of Medical Sciences (NAMS), and has received prestigious awards, Prof. B.G Prasad from Indian Society of Medical Sciences and Dr Abhaya Indrayan award for best paper from NAMS.

He presently serves as external member of several ethics and scientific committees of various intuitions. He is also Statistical Editor for the Indian Journal of Dermatology, Venerology, and Leprology and serves as Statistical Advisor of the Indian Pediatric journal.